To improve competitiveness, transport companies must pay close attention to ensuring a good balance of flows, as empty return journeys or insufficient loads can jeopardise the overall profitability of a trip. As a result, many companies, especially SMEs, are questioning the suitability of the location of their branches, or even their main premises. An analysis of the economic realities of the regions provides a better understanding of the location of the hubs that structure freight flows. Clearly, the administrative and political division of our regions does not entirely correspond to the realities of the economy, and France remains divided in two.